Synthesis of 2-Furanyl Quinolines via Zinc-Catalyzed Cascade Cyclization of Enynones with Anthranils

Yadong Feng; Pu Wang; Chaoyu Wang; Tian Wang; Xiuling Cui

doi:10.1039/d5ob01994j

January 1, 2025Organic & Biomolecular Chemistry

Synthesis of 2-Furanyl Quinolines via Zinc-Catalyzed Cascade Cyclization of Enynones with Anthranils

View Full Paper

Ask AI

Bookmark

Share

Key Points

The study aims to synthesize 2-furanyl quinolines using a zinc-catalyzed reaction involving enynones and anthranils.
Conducted zinc(II)-catalyzed cascade cyclization
Utilized enynones as substrates
Incorporated anthranils for product formation
Analyzed yields up to 91%
Achieved synthesis of 2-furanyl quinolines in yields up to 91%
Demonstrated effective ring-opening and tandem cyclization reactions
Mechanistic insights provided for the reaction pathway

Implication

Researchers developed a zinc-catalyzed process to synthesize 2-furanyl quinolines from enynones, suggesting a new pathway for organic synthesis.

Abstract

A facile Zinc(II)-catalyzed cascade cyclization of enynones with anthranils was developed to afford a series of 2-furanyl quinolines in up to 91% yield via ring-opening/tandem cyclization. Mechanistic study indicated that...

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Feng et al. (2025) studied this question.

synapsesocial.com/papers/6975b1eafeba4585c2d6d6de https://doi.org/10.1039/d5ob01994j

View Full Paper

Ask AI

Bookmark

Share

Synthesis of 2-Furanyl Quinolines via Zinc-Catalyzed Cascade Cyclization of Enynones with Anthranils

Key Points

Implication

Abstract

Discussion

Cite This Study

Synthesis of 2-Furanyl Quinolines via Zinc-Catalyzed Cascade Cyclization of Enynones with Anthranils

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading