Synthesis of Furoquinolines from 2-Alkenylanilines via Anodic Dearomatization and Cascade Cyclization

Xin Feng; Renhua Fan; Qiuqin He

doi:10.1039/d6ob00390g

January 1, 2025Organic & Biomolecular ChemistryOpen Access

Synthesis of Furoquinolines from 2-Alkenylanilines via Anodic Dearomatization and Cascade Cyclization

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Key Points

To develop a metal-free synthesis strategy for furoquinolines using anodic dearomatization and cyclization.
Performed anodic dearomatization of 2-alkenylanilines
Conducted one-pot nucleophilic cycloaddition reaction
Utilized Bischler-Napieralski reaction for cyclization
Emphasized high atom economy in the process
Successfully synthesized structurally diverse dihydrofuro[2,3-g]quinolinones
Achieved good yields in the synthesis
Demonstrated the effectiveness of the metal-free approach

Implication

This work demonstrates a novel synthesis method for diverse furoquinolines, indicating a promising metal-free approach.

Abstract

Herein, we report an anodic dearomatization followed by one-pot nucleophilic cycloaddition/Bischler-Napieralski reaction of 2alkenylanilines for the construction of structurally diverse dihydrofuro[2,3-g]quinolinones. This metal-free protocol features high atom economy and good...

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Cite This Study

Feng et al. (2025) studied this question.

synapsesocial.com/papers/69e47376010ef96374d8f39c https://doi.org/10.1039/d6ob00390g

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Synthesis of Furoquinolines from 2-Alkenylanilines via Anodic Dearomatization and Cascade Cyclization

Key Points

Implication

Abstract

Discussion

Cite This Study

Synthesis of Furoquinolines from 2-Alkenylanilines via Anodic Dearomatization and Cascade Cyclization

Key Points

Implication

Abstract

Discussion

Cite This Study

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