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This evaluation aims to assess how body weight affects contrast enhancement during coronary CT angiography using a fixed iodine-dose protocol.

January 25, 2026DiagnosticsOpen Access

Preliminary Evaluation of the Effect of Body Weight on Contrast Enhancement in Coronary CT Angiography: A Fixed Iodine-Dose Protocol

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Evaluation assesses diagnostic enhancement in coronary CT angiography, suggesting effective fixed iodine dosing protocol.

This evaluation aims to assess how body weight affects contrast enhancement during coronary CT angiography using a fixed iodine-dose protocol.
Retrospective analysis of 456 patients undergoing CCTA between January 2023 and December 2024.
Patients received a fixed dose of 75 mL contrast followed by 40 mL saline.
Independent measurement of HU values by two blinded radiologists.
Statistical comparisons using independent t-test, Mann–Whitney U test, and Chi-square test.
Statistically significant differences in HU enhancement between weight groups (p < 0.001–0.007).
All vessel segments showed mean and median HU values above the diagnostic threshold of 250 HU.
Group 1 had higher success rates for contrast enhancement (p = 0.005–0.04), except in a few specific coronary segments.

Alraddadi et al. (2026) studied this question.

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