Abstract Introduction Endoscopic sleeve gastroplasty (ESG) is a minimally invasive bariatric procedure that follows the same principles as laparoscopic sleeve gastrectomy (LSG) by reducing the usable stomach volume to decrease appetite and promote satiety. Unlike LSG, ESG does not require surgical incisions, as it is performed using an endoscopic suturing device. This study aims to evaluate the early outcomes of ESG, focusing on weight loss and postoperative complications. Methods A retrospective analysis was conducted at Dr. Napoleón Salgado Bariatric Clinic, including 17 patients who underwent ESG between January 2023 and January 2025. Collected data included demographics, body weight, body mass index (BMI), and postoperative complications before surgery and at 1, 3, and 6 months after surgery. The normal distribution of variables was assessed, and repeated measures ANOVA was used to analyze weight loss over time. Excess weight loss (%EWL) and total weight loss (%TWL) were calculated. A P-value of 0.05 was considered statistically significant. Results This cohort included 13 women and 4 men with a mean age of 41 ± 10 years, a mean initial weight of 87.8 ± 14.6 kg, and a mean BMI of 32.9 ± 4.7 kg/m². At 6-month follow-up, patients who underwent ESG achieved a mean %EWL of 96.3 ± 14.9%, %TWL of 18.2 ± 1.50%, mean weight 71.7 ± 11.8 kg, and BMI of 26.9 ± 4.1 kg/m², all which were significantly different compared to preoperative and 1-month values. However, no significant difference was observed between 3-month and 6-month measurements for %EWL (P = 0.340), %TWL (P = 0.340), BMI (P = 0.664), or weight (P = 0.662). Regarding complications, one case of NSAIDs related gastric bleeding was observed and required endoscopic intervention (Clavien-Dindo 3A), representing a rate of 5.9%. Conclusion ESG appears to be an effective and minimally invasive option for short-term weight loss, with statistically significant reductions in weight and BMI at 6 months compared to baseline. However, in this study weight loss plateaued after 3 months. Further long-term studies are needed to assess sustained outcomes and define weight loss trends in this population. Discussion: It is important to acknowledge a potential selection bias, as only patients with complete 6-month follow-up were included in the analysis. This may limit the generalizability of the findings.
Pérez et al. (Thu,) studied this question.