What question did this study set out to answer?

This research aims to investigate how lactylation and the YTHDF1 axis influence ciliary defense against Pseudomonas aeruginosa infection.

Lactylation-YTHDF1 Axis Promotes DNAH5-dependent Ciliary Defense in Pseudomonas aeruginosa Infection

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Infection alters metabolic pathways, affecting ciliary defense in airway epithelial cells, suggesting new therapeutic targets.

This research aims to investigate how lactylation and the YTHDF1 axis influence ciliary defense against Pseudomonas aeruginosa infection.
Utilized in vivo and in vitro models to study Pseudomonas aeruginosa infection effects.
Analyzed histone modifications and m6A methylation levels during the infection.
Performed m6A-seq to identify changes in DNAH5 mRNA methylation.
Assessed the impact of YTHDF1 knockout on bacterial burden.
Pseudomonas aeruginosa infection decreases lactic acid and disrupts histone lactylation.
Significant hypomethylation of DNAH5 mRNA was observed, reducing its stability.
YTHDF1 was found to be crucial for maintaining ciliary beating and mucociliary clearance.
Conditional knockout of YTHDF1 led to increased bacterial loads in mice.

Wang et al. (2026) studied this question.

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