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May 20, 2026American Journal of Respiratory and Critical Care Medicine

B28-01 Lactylation-ythdf1 Axis Promotes Dnah5-dependent Ciliary Defense in Pseudomonas Aeruginosa Infection

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Authors

JWJ WangRuijin HospitalXSX ShenChinese Academy of Medical Sciences & Peking Union Medical CollegeJQJ QuRuijin Hospital

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Implication

Randomized trial shows lactylation-YTHDF1 axis enhances ciliary defense in mice, highlighting a potential therapeutic target.

Key Points

  • This research investigates the role of the lactylation-YTHDF1-DNAH5 axis in ciliary defense during Pseudomonas aeruginosa infection.
  • Used in vivo and in vitro models including YTHDF1 knockout C57BL/6 mice and various cell lines.
  • Assessed bacterial burden, ciliary beat frequency, and mucociliary transport using high-speed video microscopy and CFU quantification.
  • Conducted m6A-sequencing, RNA immunoprecipitation-qPCR, and histone lactylation assays.
  • Pseudomonas aeruginosa infection led to decreased lactate levels, reducing H3K18la and downregulating YTHDF1.
  • YTHDF1 deficiency abolished ciliary beat frequency and increased bacterial colonization and inflammation.
  • Exogenous lactic acid restored ciliary function, indicating the potential for targeted therapeutic approaches.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a0d4fa9f03e14405aa9b172https://doi.org/10.1093/ajrccm/aamag162.4242
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The lactylation-YTHDF1 axis promotes DNAH5-dependent ciliary defense in Pseudomonas aeruginosa infection2026 · 3 citations
  2. 2YY1 lactylation mediates epithelial barrier dysfunction during acute lung injury2026
  3. 3The bacterial quorum-sensing molecule 2’-aminoacetophenone reprograms macrophage metabolism and sustains histone lactylation for persistence 22536612026
  4. 4Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP32025 · 4 citations
  5. 5YTHDF1-CLOCK axis contributes to pathogenesis of allergic airway inflammation through LLPS2024 · 19 citations