What question did this study set out to answer?

This research aims to evaluate the biological properties of Glycyrrhiza glabra methanolic extract for treating rosacea.

January 25, 2026AntioxidantsOpen Access

Formulation and Biological Evaluation of Glycyrrhiza glabra L. Methanolic Extract: An Exploratory Study in the Context of Rosacea

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Exploratory study assesses Glycyrrhiza glabra effects on rosacea, indicating potential benefits for skin care formulations.

This research aims to evaluate the biological properties of Glycyrrhiza glabra methanolic extract for treating rosacea.
Formulated xanthan-gum hydrogels with 2% Gg extract for topical application.
Conducted rheology, release, and permeation tests for formulation assessment.
Evaluated antioxidant activity using DPPH, ABTS, and FRAP assays.
Tested antimicrobial effects against specific bacteria.
Assessed cytocompatibility and safety in HaCaT keratinocyte assays.
Hydrogels demonstrated strong antioxidant activity and suitable rheology.
Moderate antimicrobial effects were noted, especially against S. pyogenes and C. acnes.
HaCaT cell viability exceeded 84% for formulation S2 at the highest concentration, showing better cytocompatibility than S1.
Hydrogels were non-irritant in the HET-CAM test and reduced vascular growth in the CAM assay.
Immunohistochemistry revealed modulation of inflammatory pathways, with significant results for formulation S2.

Semenescu et al. (2026) studied this question.

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