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January 25, 20260 citations

Natural Product-Based Virtual Screening Identifies Potential Inhibitors of Feline Coronavirus 3CLpro.

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ZJZunyun JiangNanjing Agricultural UniversityHCHongyi ChenNanjing Agricultural UniversityWXWang XiongNanjing Agricultural University

Key Points

  • The study aims to identify potential inhibitors of feline coronavirus 3CLpro using natural product-based virtual screening.
  • Conducted virtual screening of natural compounds.
  • Focused on identifying strong antiviral candidates.
  • Analyzed core molecular frameworks for inhibitor potential.
  • Identified several compounds with strong antiviral potential.
  • Revealed molecular frameworks for designing new inhibitors.
  • Laid the groundwork for further structure-guided drug discovery.

Abstract

The findings indicated the compounds' strong potential for further development as antiviral leads. The results also revealed several core molecular frameworks that may serve as an initial reference for designing FCoV 3CLpro inhibitors, laying the groundwork for structure-guided drug discovery efforts.

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Cite This Study

Jiang et al. (2026) studied this question.

synapsesocial.com/papers/6975b4fd5a65d392b01e5d03https://doi.org/10.2174/0115680266426906251125112131
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Repurposing FDA-Approved Drugs as Potential Inhibitors of Feline Infectious Peritonitis Virus 3CL pro : An Integrated In Silico and In Vitro Study with Synergistic Combination Analysis2026
  2. 2Compound C inhibits the replication of feline coronavirus2024 · 2 citations
  3. 3Structural Analysis of Inhibitor Binding to the Feline Enteric Coronavirus (FECV) Main Protease2025
  4. 4Identification of potential inhibitors of the main protease from feline infectious peritonitis virus using molecular docking and dynamic simulation approaches2025 · 6 citations
  5. 5Applications of some artificial intelligence tools in the drug design of some compounds targeting the main viral protease of the Feline Infectious Peritonitis Virus (FIPV) in cats2024 · 1 citations