Key result
Obstructive sleep apnea linked to increased CV risk via amplified BP variability and autonomic disruption.
Why the study?
To synthesize current understanding of the potential interrelations between obstructive sleep apnea, autonomic disturbances, blood pressure variability patterns, and their cardiovascular risk consequences.
Key points are not available for this paper at this time.
Design
Brief review
Supports OSA evaluation in high BP variability; supports consensus on autonomic mechanisms but leaves causal effects open.
Augmented blood pressure variability has emerged as a quantity predictive of adverse cardiovascular outcomes. Among the range of intrinsic and extrinsic factors shown to increase night-time, circadian, short-term, and long-term blood pressure variations, the presence and severity of obstructive sleep apnea have emerged as one of the most prevalent and potent. Obstructive sleep apnea alters acutely the normal nocturnal equilibrium between sympathetic and parasympathetic tone, magnifying nocturnal blood pressure oscillations, and induces sustained autonomic aftereffects with the capacity to amplify short-term and intersessional blood pressure variabilities. The object of this brief review is to synthesize the current understanding of the potential interrelations between obstructive sleep apnea, the acute and sustained autonomic disturbances that it elicits, and beat-to-beat blood pressure fluctuation during sleep, nocturnal dipping status, and day-to-day blood pressure variability and the consequences of these perturbations for cardiovascular risk.
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Tobushi et al. (2024) studied this question. Obstructive sleep apnea significantly amplifies blood pressure variability and disrupts autonomic balance, increasing cardiovascular risk.
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