Key result
Proton pump inhibitors are not associated with an increased risk of major congenital birth defects, spontaneous abortions, or preterm delivery in pregnancy.
Why the study?
Does Proton Pump Inhibitors (PPIs) increase major congenital birth defects, spontaneous abortions, or preterm delivery in pregnant women?
Does Proton Pump Inhibitors (PPIs) increase major congenital birth defects, spontaneous abortions, or preterm delivery in pregnant women?
Proton pump inhibitors can be safely used in pregnancy without increasing the risk of major adverse pregnancy or fetal outcomes.
Supports safe PPI use in pregnancy; reinforces consensus from prior observational data.
On the basis of these results, PPIs are not associated with an increased risk for major congenital birth defects, spontaneous abortions, or preterm delivery. The narrow range of 95% CIs is further reassuring, suggesting that PPIs can be safely used in pregnancy.
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Gill et al. (2009) studied this question. Proton pump inhibitors are not associated with an increased risk of major congenital birth defects, spontaneous abortions, or preterm delivery in pregnancy.
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