Key result
Elevated resting heart rate is linked to increased cardiovascular and all-cause mortality across populations.
Why the study?
Resting heart rate is associated with adverse outcomes and mortality, but an overview synthesising physiological mechanisms, normal cutoffs, and risk-reduction interventions was needed.
This review highlights resting heart rate as a significant cardiovascular risk factor associated with increased mortality, suggesting its utility in guiding risk-reduction interventions.
Supports resting heart rate monitoring for risk stratification; confirms observational links but leaves causal benefit of reduction open.
Heart rate is a parameter that is widely used by the general population as a marker of health. The availability of wearable electronic heart rate monitoring devices and use of specific apps are widely used both at rest and during daily life activities. Resting heart rate values gained more relevance with the evidence of association between elevated heart rate values at rest and diseases and adverse events. Also longitudinal studies demonstrated a clear association between increase in heart rate over time and cardiovascular and all-cause mortality. The increased knowledge of physiological mechanisms of heart rate control and the pathophysiological mechanisms responsible for its dysfunction allows identification of the cutoff value of normalcy. This information can be used to select non-pharmacological and pharmacological interventions to reduce the cardiovascular risk both in the general population and in patients with pathophysiological conditions. This review provides an overview of the current knowledge of resting heart rate as cardiovascular risk factor.
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Seravalle et al. (2020) studied this question. Elevated resting heart rate is associated with increased cardiovascular and all-cause mortality in both the general population and patients with health conditions.
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