Key result
E-ISR exhibits ~6-fold more homogeneous neointima than L-ISR.
Why the study?
Do neointimal tissue characteristics differ between early and late in-stent restenosis after second-generation drug-eluting stent implantation?
Observational (n=53)
No
Do neointimal tissue characteristics differ between early and late in-stent restenosis after second-generation drug-eluting stent implantation?
Absolute Event Rate: 26.7% vs 4.4%
p-value: p=0.02
Early in-stent restenosis after second-generation DES is primarily driven by neointimal hyperplasia, whereas late restenosis is predominantly caused by neoatherosclerosis.
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Observational data support distinct ISR mechanisms by timing; leaves open targeted therapy implications after second-generation DES.
Jinnouchi et al. (2017) conducted an observational in in-stent restenosis after second-generation drug-eluting stents (n=53). Second-generation drug-eluting stents vs. Bare-metal stents was evaluated on Differences in neointimal tissue characteristics between early (E-ISR) and late (L-ISR) in-stent restenosis (p=0.02). Early in-stent restenosis (E-ISR) exhibited homogeneous neointima in 26.7% of cases compared to 4.4% in late in-stent restenosis (L-ISR), with a P-value of 0.02.
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