Key result
Very late in-stent restenosis (>5 years) after bare-metal stenting showed a significantly higher proportion of heterogeneous intima compared to early restenosis (60.5% vs 5.8%, P<0.0001).
Why the study?
Are the morphological characteristics of very late in-stent restenosis different from early in-stent restenosis after bare-metal stent implantation?
Population
82 patients with in-stent restenosis after bare-metal stent implantation
Comparison
Very late in-stent restenosis vs Early in-stent restenosis (within the first year)
Design
Cohort
Authors
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Distinct OCT features in very late versus early BMS ISR suggest differing mechanisms; leaves open targeted therapy implications.
Observational (n=82)
Are the morphological characteristics of very late in-stent restenosis different from early in-stent restenosis after bare-metal stent implantation?
Absolute Event Rate: 60.5% vs 5.8%
p-value: p=<0.0001
Very late in-stent restenosis after bare-metal stent implantation exhibits morphological characteristics similar to atherosclerotic plaque, suggesting neoatherosclerosis progression.
Habara et al. (2011) conducted an observational in In-stent restenosis after bare-metal stent implantation (n=82). Very late in-stent restenosis (>5 years) vs. Early in-stent restenosis (within 1 year) was evaluated on Proportion of cross-sections with heterogeneous intima in the entire stent (p=<0.0001). Very late in-stent restenosis (>5 years) after bare-metal stenting showed a significantly higher proportion of heterogeneous intima compared to early restenosis (60.5% vs 5.8%, P<0.0001).
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