What question did this study set out to answer?

The study investigates how reduced axonal outgrowth and dendritic changes in old mice contribute to long-lasting memory dysfunction following a stroke.

February 2, 2026Stroke

Abstract TP088: Decreased axonal outgrowth and dendritic plasticity, and increased synaptic removal in hippocampal and cortical neurons contribute to the long-lasting post-stroke memory dysfunction in old mice

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The study investigates how reduced axonal outgrowth and dendritic changes in old mice contribute to long-lasting memory dysfunction following a stroke.
Induced ischemic stroke in young and old mice.
Assessed memory functions using Y-maze and novel object recognition tests.
Collected brains for RNA sequencing and Golgi staining at 8 weeks post-stroke.
Performed Sholl analysis to study dendritic structures.
Old mice showed long-term memory dysfunction and larger infarct volumes compared to young mice.
Measured neurite lengths were shorter in old mice, with fewer neurites and dendritic spines in affected brain regions.
Sholl analysis indicated reduced dendritic intersections in old mice compared to young mice.
Inflammatory pathways were upregulated while axon guidance pathways were downregulated in old mice after stroke.

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Implication

Reveals increased synaptic removal and decreased axonal and dendritic functions in old mice post-stroke, suggesting pathways for neuroprotective treatments.

Cite This Study

nabikandi et al. (2026) studied this question.

synapsesocial.com/papers/6980fbbec1c9540dea80d7cc https://doi.org/10.1161/str.57.suppl_1.tp088

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Implication

Reveals increased synaptic removal and decreased axonal and dendritic functions in old mice post-stroke, suggesting pathways for neuroprotective treatments.

Abstract TP088: Decreased axonal outgrowth and dendritic plasticity, and increased synaptic removal in hippocampal and cortical neurons contribute to the long-lasting post-stroke memory dysfunction in old mice

Key Points

Discussion

Implication

Cite This Study

Abstract TP088: Decreased axonal outgrowth and dendritic plasticity, and increased synaptic removal in hippocampal and cortical neurons contribute to the long-lasting post-stroke memory dysfunction in old mice

Key Points

Discussion

Implication

Cite This Study

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