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This research seeks to investigate long-term deficits and tissue changes following ischemic stroke in mice of different ages.

Abstract Number: Esoc2026a1894 Translational Chronic Deficits and Tissue Changes After Large Stroke, in Young- And Old-Aged Mice

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This research seeks to investigate long-term deficits and tissue changes following ischemic stroke in mice of different ages.
Young (3 months) and old (14 months) male C57BL/6N mice underwent 1-hour transient middle cerebral artery occlusion (fMCAo).
Mice were monitored behaviorally and clinically for 6 months post-surgery, utilizing various tests for neurological status and physical activity.
Post-mortem analysis involved cryosectioning the brains and spinal cords to assess tissue changes and cellular responses.
Older mice demonstrated significantly higher acute mortality due to edema-related complications (p<0.05).
Both age groups exhibited a 30% decrease in ipsilesional hemispheric volume after 6 months, alongside chronic sensory cortex atrophy and increased microglial activity.
Surviving mice showed persistent sensorimotor impairments and weight loss beyond one month post-stroke.

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Randomized trial demonstrates long-term tissue changes post-stroke in young and old mice, suggesting chronic targets for therapy.

Karvelas et al. (2026) studied this question.

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