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February 2, 2026Stroke

Abstract WP161: Comparative Trends in Mortality from Ischemic and Hemorrhagic Stroke in the United States, 1999–2020

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Key result

Ischemic stroke mortality rebounds sharply after 2014, especially among younger adults, while racial disparities persist.

Why the study?

Recent shifts in stroke mortality necessitated an updated evaluation of ischemic and hemorrhagic stroke deaths across demographics and geographic regions in the United States.

Population

435,402 ischemic and 681,756 hemorrhagic stroke deaths in adults aged ≥25 years

Comparison

Ischemic stroke vs hemorrhagic stroke mortality stratified by sex, race/ethnicity, and region

Design

Retrospective database analysis using CDC WONDER

Authors

SHSheraz HakeemAga Khan UniversityAAAmna AhmadCMH Lahore Medical College and Institute of DentistryMDMuhammad DaniyalMontefiore Medical Center

Discussion

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Implication

Reversing ischemic stroke mortality trends since 2014, especially in younger adults, may prompt renewed prevention focus; challenges prior consensus and leaves open drivers.

Key Points

  • The aim is to evaluate trends in mortality from ischemic and hemorrhagic strokes in the U.S. across different demographics from 1999 to 2020.
  • Analyzed national mortality data from the CDC WONDER database for adults aged 25 and older.
  • Identified stroke deaths using ICD-10 codes.
  • Calculated age-adjusted mortality rates and stratified by sex, race/ethnicity, and region.
  • Evaluated temporal trends with Joinpoint regression.
  • Ischemic stroke mortality decreased from 1999 to 2014 but sharply increased through 2020, especially in younger adults.
  • Hemorrhagic stroke mortality declined until 2012 but plateaued or slightly increased afterward.
  • Non-Hispanic Blacks had the highest age-adjusted mortality rates for both stroke types.
  • The South had the highest regional mortality rates for both ischemic and hemorrhagic strokes.

Structured PICO

P
Population
1,117,158 stroke deaths (435,402 ischemic, 681,756 hemorrhagic) among adults aged ≥25 years in the United States from 1999 to 2020.
O
Outcome
Age-adjusted mortality rates (AAMRs) and annual percent changes (APCs) for ischemic and hemorrhagic strokehard clinical

Recent increases in stroke mortality since 2014, particularly for ischemic stroke among younger adults and vulnerable populations, highlight the need for improved public health strategies and targeted interventions.

Cite This Study

Hakeem et al. (2026) studied this question. Ischemic stroke mortality steadily declined until 2014, then sharply increased by 2020, especially in younger adults, while disparities persisted across racial groups.

synapsesocial.com/papers/6980fbbec1c9540dea80d8echttps://doi.org/10.1161/str.57.suppl_1.wp161
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract TP180: Trends and Disparities in Hemorrhagic Stroke-associated Mortality Among Adults in the United States: A Centers for Disease Control and Prevention (CDC) WONDER Analysis (1999-2023)2026
  2. 2Stroke mortality in the United States from 1968 to 2023: A CDC WONDER analysis2025 · 8 citations
  3. 3Abstract HUP9: Divergent Temporal Trends in Ischemic and Hemorrhagic Stroke Mortality in the United States: A CDC WONDER Database Analysis2026
  4. 4Five‐Decade Mortality Trends in Ischemic Stroke in the United States: A CDC WONDER Analysis2025 · 7 citations
  5. 5Abstract TP120: Trends In Stroke And Ischemic Heart Disease Related Mortality Among Older Adults Aged 45 Years And Older In The United States A 25 Year Retrospective Analysis 1999–20232026