Why the study?
Despite advances in diagnosis, treatment, and prevention of ischemic stroke, significant disparities and geographic variability persist in the United States, highlighting the need for targeted strategies.
Population
1,363,668 ischemic stroke deaths from US death certificate data
Comparison
Mortality trends compared across age, sex, and race/ethnicity
Design
Retrospective epidemiological study using joinpoint regression
Key result
Ischemic stroke mortality declined from 76.2 to 10.0 per 100,000 from 1968 to 2023, but recent increases were observed post-2014, particularly in older adults.
Authors
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Recent post-2014 rises warrant monitoring in older adults; extends long-term trends but leaves reversal drivers open.
Despite a long-term decline over five decades, ischemic stroke mortality in the US has recently increased since 2014, highlighting the need for renewed targeted prevention strategies.
Qasim et al. (2025) studied this question. Ischemic stroke mortality declined from 76.2 to 10.0 per 100,000 from 1968 to 2023, but recent increases were observed post-2014, particularly in older adults.
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