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A multi-center trial shows nortriptyline lacks effectiveness for FD symptoms, suggesting belief effects may play a role.
Nortriptyline was not more effective than placebo in reducing FD symptoms in participants pre-selected based on CYP2D6 genotype, although a biological effect of nortriptyline could not be ruled out. However, effects related to participants' belief appeared to be stronger; Clinicaltrials.gov number, NCT03652571.
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Bosch et al. (2026) studied this question.
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