Why the study?
Does fluoxetine compared to nortriptyline improve depression symptoms in adult outpatients with moderate to severe major depression?
Population
48 adult outpatients with moderate to severe major depression, baseline Hamilton Rating Scale for Depression…
Comparison
Fluoxetine 60 mg/day for 6 weeks vs Nortriptyline 150 mg/day for 6 weeks
Design
RCT, randomly assigned, double-blind
Follow-up
6 weeks
Authors
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Nortriptyline may warrant consideration over fluoxetine for moderate-severe depression; extends head-to-head RCT evidence on efficacy and QTc safety.
Does fluoxetine compared to nortriptyline improve depression symptoms in adult outpatients with moderate to severe major depression?
In a small trial of moderate to severe major depression, nortriptyline was more effective than fluoxetine, though with more anti-cholinergic side effects.
Akhondzadeh et al. (2003) studied this question.
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