Why the study?
Does paroxetine improve depression and cardiovascular safety compared to nortriptyline in depressed patients with ischemic heart disease?
Population
81 outpatients meeting Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria for…
Comparison
Paroxetine, 20 to 30 mg/d for 6 weeks vs Nortriptyline targeted to a therapeutic plasma…
Design
RCT, Randomized, Double-blind
Follow-up
6 weeks
Authors
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Paroxetine should be preferred over nortriptyline in depressed patients with ischemic heart disease; confirms comparable efficacy with superior cardiac safety.
Does paroxetine improve depression and cardiovascular safety compared to nortriptyline in depressed patients with ischemic heart disease?
In depressed patients with ischemic heart disease, paroxetine and nortriptyline are similarly effective for depression, but nortriptyline is associated with a significantly higher rate of serious adverse cardiac events.
Steven P. Roose (1998) studied this question.
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