Key result
Paroxetine showed no significant differences in overall antidepressant efficacy compared to amitriptyline after 6 weeks, but displayed significantly fewer instances of dry mouth and dizziness.
Why the study?
Does paroxetine improve depression in patients with endogenous depressive illnesses compared to amitriptyline?
Population
44 patients with depressive illnesses of an endogenous nature
Comparison
Paroxetine for 6 weeks vs Amitriptyline for 6 weeks
Design
RCT, randomized, double-blind
Follow-up
6 weeks
Authors
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Supports paroxetine over amitriptyline for endogenous depression given comparable efficacy and superior tolerability; confirms SSRI advantages in randomized settings.
RCT (n=44)
Double-blind
Does paroxetine improve depression in patients with endogenous depressive illnesses compared to amitriptyline?
Paroxetine is as effective as amitriptyline for endogenous depression but has a more favorable side effect profile regarding dry mouth and orthostatic dizziness.
Laursen et al. (1985) conducted an RCT in Depression (n=44). Paroxetine vs. Amitriptyline was evaluated on Antidepressant effect measured by the 17-item Hamilton Depression Scale. Paroxetine showed no significant differences in overall antidepressant efficacy compared to amitriptyline after 6 weeks, but displayed significantly fewer instances of dry mouth and dizziness.
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