Key result
Nortriptyline and phenelzine cause greater orthostatic falls in systolic pressure versus placebo.
Why the study?
Does nortriptyline or phenelzine increase orthostatic fall in systolic pressure compared to placebo in elderly patients with major depression?
Population
75 patients, 55 years or older, with major depression
Comparison
Nortriptyline or phenelzine for 7 weeks vs Placebo
Design
RCT, placebo-controlled
Follow-up
7 weeks
Authors
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Warrants orthostatic BP monitoring in elderly patients on nortriptyline or phenelzine; confirms comparable risk with both agents.
RCT (n=75)
Does nortriptyline or phenelzine increase orthostatic fall in systolic pressure compared to placebo in elderly patients with major depression?
In elderly depressed patients, both nortriptyline and phenelzine cause a significant orthostatic fall in systolic blood pressure compared to placebo.
Georgotas et al. (1987) conducted an RCT in major depression (n=75). Nortriptyline and phenelzine vs. Placebo was evaluated on mean orthostatic fall in systolic pressure. Nortriptyline and phenelzine caused a significantly greater mean orthostatic fall in systolic pressure compared to placebo, with no significant difference between the active drugs.
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