Why the study?
Does phenelzine improve depression compared to placebo and amitriptyline, and is efficacy dependent on the degree of MAO inhibition in depressed patients?
Population
depressed patients
Comparison
phenelzine vs amitriptyline and placebo
Design
RCT, double-blind
Follow-up
5 weeks
Authors
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Supports MAO inhibition monitoring to optimize phenelzine dosing in depression; confirms threshold-dependent efficacy in RCT evidence.
Does phenelzine improve depression compared to placebo and amitriptyline, and is efficacy dependent on the degree of MAO inhibition in depressed patients?
The clinical efficacy of phenelzine in treating depression is highly correlated with achieving at least 80-90% inhibition of platelet MAO activity.
Raft et al. (2008) studied this question.
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