Key result
Phenelzine and mianserin did not alter cardiac conduction, whereas tricyclic antidepressants caused expected conduction prolongation and increased heart rate.
Why the study?
Do phenelzine and mianserin affect heart rate and cardiac conduction compared to tricyclic antidepressants and placebo?
Comparison
Phenelzine and mianserin vs Imipramine, amitriptyline, and placebo
Design
Other
Authors
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May support safer alternatives to tricyclics in cardiac patients; hypothesis-generating and requires randomized confirmation before practice change.
RCT
Do phenelzine and mianserin affect heart rate and cardiac conduction compared to tricyclic antidepressants and placebo?
Phenelzine and mianserin do not prolong cardiac conduction compared to tricyclic antidepressants, suggesting they may be safer alternatives for patients with cardiac disease.
McGrath et al. (1987) reported an RCT. Phenelzine and mianserin vs. Imipramine, amitriptyline, and placebo was evaluated on Cardiographic effects including heart rate and cardiac conduction. Phenelzine and mianserin did not alter cardiac conduction, whereas tricyclic antidepressants caused expected conduction prolongation and increased heart rate.
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