Key result
Mianserin avoids the heart rate and PR interval increases seen with amitriptyline.
Why the study?
The cardiac effects of mianserin compared to amitriptyline in the treatment of depressive illness were not well characterized.
Does mianserin have fewer cardiotoxic ECG effects than amitriptyline in female patients with depressive illness?
Population
27 female patients with depressive illness
Comparison
Mianserin versus amitriptyline
Design
Double-blind comparative trial
Follow-up
3 weeks
Authors
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Mianserin may be preferred over amitriptyline when ECG safety is a concern; confirms differential cardiotoxicity in this RCT of depressed women.
RCT (n=27)
Double-blind
Does mianserin have fewer cardiotoxic ECG effects than amitriptyline in female patients with depressive illness?
Mianserin lacks the cardiotoxic effects (increased heart rate and PR interval) seen with amitriptyline after 3 weeks of treatment in depressed female patients.
Peet et al. (1977) conducted an RCT in depressive illness (n=27). Mianserin vs. Amitriptyline was evaluated on Changes in E.C.G. parameters (heart rate, PR interval, QRS width, T wave amplitude). Mianserin lacked cardiotoxic effects on ECG parameters, whereas amitriptyline significantly increased heart rate and PR interval compared to mianserin after three weeks of treatment.
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