Why the study?
Do amitriptyline, mianserin, zimelidine, and nomifensine alter systolic time intervals and ECG parameters in depressed patients?
Population
Depressed patients
Design
Cohort
Authors
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Amitriptyline-associated contractility changes may warrant caution in cardiac patients; leaves open whether these systolic time interval shifts predict outcomes or apply to newer agents.
Do amitriptyline, mianserin, zimelidine, and nomifensine alter systolic time intervals and ECG parameters in depressed patients?
Amitriptyline decreases cardiac contractility and exhibits quinidine-like effects, whereas mianserin's cardiovascular changes are likely due to peripheral circulation effects.
Burgess et al. (1979) studied this question.
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