Why the study?
Does amitriptyline compared to zimelidine alter cardiovascular hemodynamics in depressed patients?
Population
12 depressed patients
Comparison
Amitriptyline vs Zimelidine
Design
RCT, randomized, double-blind
Follow-up
14 days
Authors
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Amitriptyline may compromise hemodynamics in depressed patients; supports preferring zimelidine over TCAs when cardiovascular risk is present.
Does amitriptyline compared to zimelidine alter cardiovascular hemodynamics in depressed patients?
Zimelidine demonstrates a more favorable cardiovascular hemodynamic profile compared to amitriptyline, suggesting it may be a safer option for depressed patients with cardiovascular disease.
Christie et al. (1981) studied this question.
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