Why the study?
Does amitriptyline or zimeldine affect car driving and psychomotor performance in volunteers?
Population
Volunteers
Comparison
Amitriptyline and zimeldine (acute, single dose) vs Placebo
Design
Other, Placebo-controlled
Follow-up
4 hours post-treatment
Authors
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Amitriptyline may warrant driving caution acutely in volunteers; leaves open translation to patients or chronic use.
Does amitriptyline or zimeldine affect car driving and psychomotor performance in volunteers?
Amitriptyline significantly impairs driving and psychomotor performance acutely, whereas zimeldine does not.
Hindmarch et al. (1983) studied this question.
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