Key result
Mianserin preserves cardiac contractility, whereas amitriptyline causes a ~17% decline in healthy volunteers.
Why the study?
The cardiac effects of mianserin compared to amitriptyline, particularly on myocardial contractility, were not well characterized in healthy volunteers.
Does mianserin compared to amitriptyline preserve myocardial contractility in healthy volunteers?
Comparison
Mianserin vs amitriptyline with increasing doses
Design
Randomized allocation to two groups
Follow-up
6 days
Authors
Loading...
May warrant contractility monitoring with amitriptyline; leaves open clinical relevance in cardiac patients.
RCT (n=10)
Does mianserin compared to amitriptyline preserve myocardial contractility in healthy volunteers?
Mianserin does not decrease cardiac contractility compared to amitriptyline, suggesting it may be a safer antidepressant choice for patients with cardiac disease.
Wester et al. (1980) conducted an RCT in Healthy volunteers (n=10). Mianserin vs. Amitriptyline was evaluated on Myocardial contractility. Mianserin did not decrease cardiac contractility after 6 days of treatment, whereas amitriptyline caused a 17% loss of myocardial contractility in healthy volunteers.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: