Why the study?
Does mianserin or amitriptyline improve depression scores compared to placebo in outpatients with major depression?
Population
149 outpatients with major depression (DSM-III 296.2 or 296.3)
Comparison
Mianserin or amitriptyline for 42 days vs Placebo (up to five capsules nightly)
Design
RCT, randomized, double-blind
Follow-up
42 days
Authors
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Supports mianserin for faster onset in major depression; confirms RCT efficacy of both agents versus placebo in outpatients.
Does mianserin or amitriptyline improve depression scores compared to placebo in outpatients with major depression?
Mianserin is an effective and well-tolerated treatment for major depression, with efficacy comparable to amitriptyline but potentially faster onset and fewer anticholinergic side effects like dry mouth.
Wilcox et al. (1994) studied this question.