Key result
Pretreatment systolic orthostatic pressure changes strongly correlated with improvement on the Beck Depression Inventory in depressed elderly outpatients treated with nortriptyline (r=0.74, p<0.01).
Why the study?
Does pretreatment orthostatic hypotension predict response to nortriptyline in unipolar depressed elderly outpatients?
Population
Unipolar depressed elderly outpatients (mean age, 64)
Comparison
16-week course of nortriptyline vs 16-week course of interpersonal psychotherapy
Design
Cohort
Follow-up
16 weeks
Authors
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Hypothesis-generating for orthostatic changes predicting nortriptyline response in elderly depression; prospective trials needed before clinical adoption.
Observational
Does pretreatment orthostatic hypotension predict response to nortriptyline in unipolar depressed elderly outpatients?
Effect estimate: r = 0.74
p-value: p=<0.01
Pretreatment orthostatic hypotension, traditionally considered a relative contraindication to tricyclic antidepressants, may actually identify elderly depressed patients more likely to respond to nortriptyline.
SCHNEIDER et al. (1986) conducted an observational in Unipolar depression. Pretreatment systolic orthostatic pressure changes (PSOP) vs. Interpersonal psychotherapy was evaluated on Improvement on the Beck Depression Inventory (r = 0.74, p=<0.01). Pretreatment systolic orthostatic pressure changes strongly correlated with improvement on the Beck Depression Inventory in depressed elderly outpatients treated with nortriptyline (r=0.74, p<0.01).
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