What question did this study set out to answer?

Evaluate the safety, feasibility, and preliminary efficacy of Remote Administration of Hypothermia (RAH) in neuroprotection after mechanical thrombectomy for acute ischemic stroke.

February 2, 2026Stroke

Abstract TP305: A Novel Adjuvant Strategy for Futile Reperfusion after Endovascular Therapy: Remote Administration of Hypothermia (RAH) from Peripheral Orgain for Neuroprotection in CNS

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Evaluate the safety, feasibility, and preliminary efficacy of Remote Administration of Hypothermia (RAH) in neuroprotection after mechanical thrombectomy for acute ischemic stroke.
Prospective randomized controlled trial with 40 acute ischemic stroke patients
Randomization into RAH and control groups following successful mechanical thrombectomy
RAH applied via ice packs over the splenic region for 6 hours post-recanalization
No severe adverse events or frostbite were reported, confirming safety
RAH group showed a trend toward increased spleen volume, indicating reduced splenic contraction
Interleukin-5 levels increased significantly in the RAH group after 5–7 days
Favorable trends in 90-day functional independence and reduced infarct volume were noted, though not statistically significant

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Implication

Prospective trial assesses safety and efficacy of hypothermia therapy post-thrombectomy, suggesting implications for recovery.

Cite This Study

Geng et al. (2026) studied this question.

synapsesocial.com/papers/6980fbf6c1c9540dea80dc97 https://doi.org/10.1161/str.57.suppl_1.tp305

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Abstract TP305: A Novel Adjuvant Strategy for Futile Reperfusion after Endovascular Therapy: Remote Administration of Hypothermia (RAH) from Peripheral Orgain for Neuroprotection in CNS

Key Points

Discussion

Implication

Cite This Study

Abstract TP305: A Novel Adjuvant Strategy for Futile Reperfusion after Endovascular Therapy: Remote Administration of Hypothermia (RAH) from Peripheral Orgain for Neuroprotection in CNS

Key Points

Discussion

Implication

Cite This Study

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