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February 2, 2026GenesOpen Access

Assessing Genetic Risk for Physical Activity and Its Interaction with Diet in Predicting Activity Levels and Weight Loss in the iMPROVE Study

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Authors

MKMaria KafyraPSPanagiotis SymianakisEPEleonora Porcu

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Overview

Analysis evaluates genetic risk and dietary habits in predicting activity and weight changes in adults, suggesting complex interactions.

Key Points

  • The study aims to evaluate the predictive value of polygenic risk scores for physical activity and weight outcomes, particularly in interaction with diet.
  • Analyzed baseline data from 202 participants in the iMPROVE study
  • Calculated polygenic risk scores for 197 participants
  • Operationalized physical activity using metabolic equivalent of task minutes per week
  • Examined interactions between genetic data and dietary patterns with correlation analyses and regression models
  • Polygenic risk score PGS002254 showed a significant interaction with diet for weight loss post-intervention (p = 0.04)
  • Sedentary behavior score PGS001923 had a significant interaction with a dietary pattern for MET-mins/week (p = 0.001)
  • Genetic predisposition influences activity and weight outcomes but has modest explanatory power

Cite This Study

Kafyra et al. (2026) studied this question.

synapsesocial.com/papers/6980fc37c1c9540dea80e03ahttps://doi.org/10.3390/genes17020155
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract P492: Polygenic Risk for Obesity and Race Modify the Effect of a Low Fat Dietary Clinical Trial on Weight Loss2024
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  3. 3Physical Activity and Incident Obesity Across the Spectrum of Genetic Risk for Obesity2024 · 22 citations
  4. 4Effect of a Dietary Intervention on Weight Loss in Adults with High vs Low Genetic Predisposition to Higher BMI: A Randomized Diet Intervention Trial2025 · 2 citations
  5. 5Developing a Polygenic Risk Score for Weight Gain in People Treated for Psychosis—Application in a Real‐World Setting2026 · 1 citations