What question did this study set out to answer?

Assess how genetic and lifestyle factors impact body composition and metabolic syndrome risk factors.

Genetic determinants of BMI, diet, and fitness interact to partially explain anthropometric obesity traits but not the metabolic consequences of obesity in men and women

View Full Paper

Ask AI

Bookmark

Authors

Cross-sectional analysis reveals genetic and lifestyle factors influence obesity traits, indicating the need for tailored approaches.

Assess how genetic and lifestyle factors impact body composition and metabolic syndrome risk factors.
Cross-sectional analysis of 211 participants aged 18-66 from the USDA Nutritional Phenotyping Study.
Calculation of body mass index (BMI) polygenic risk scores using the pgs_calc pipeline.
Assessment of associations with body composition and metabolic syndrome traits using linear regression and ANCOVA.
The PRS explained 15.6% of BMI variance; independent factors accounted for 11.3%.
Mixed associations found between diet quality, fitness, resting metabolic rate, and obesity traits.
Only waist circumference and plasma glucose showed slight connections with PRS, while blood pressure and HDL levels did not.

Arrington et al. (2026) studied this question.

View Full Paper

Ask AI

Bookmark