What question did this study set out to answer?

This analysis aims to evaluate the effectiveness and safety of glibenclamide in improving neurological outcomes post-stroke.

February 2, 2026Stroke

Abstract A143: Clinical effectiveness and Safety of Glibenclamide in Post-Stroke Patients: A Systematic Review and Meta-analysis of Randomized Controlled Trials

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This analysis aims to evaluate the effectiveness and safety of glibenclamide in improving neurological outcomes post-stroke.
Conducted a systematic review and meta-analysis of randomized controlled trials
Analyzed data from Pubmed, Embase, and Cochrane databases
Included studies comparing glibenclamide to placebo
Assessed functional outcomes using the Modified Rankin Score after 90 days
No significant difference in functional outcomes compared to placebo
Hypoglycemia occurred more frequently in patients treated with glibenclamide
No notable changes in the rates of decompressive craniectomy or mortality observed

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Implication

Systematic review examines glibenclamide's effects on outcomes in post-stroke patients, suggesting no significant benefits and increased hypoglycemia risk.

Cite This Study

Damaceno et al. (2026) studied this question.

synapsesocial.com/papers/6980fc73c1c9540dea80e4d0 https://doi.org/10.1161/str.57.suppl_1.a143

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Implication

Systematic review examines glibenclamide's effects on outcomes in post-stroke patients, suggesting no significant benefits and increased hypoglycemia risk.

Abstract A143: Clinical effectiveness and Safety of Glibenclamide in Post-Stroke Patients: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Key Points

Discussion

Implication

Cite This Study

Abstract A143: Clinical effectiveness and Safety of Glibenclamide in Post-Stroke Patients: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Key Points

Discussion

Implication

Cite This Study

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