Why the study?
It was unknown whether glibenclamide reduces cerebral edema and improves neurological functioning in patients with aneurysmal subarachnoid hemorrhage.
Does oral glibenclamide improve functional outcomes and reduce cerebral edema in patients with aneurysmal subarachnoid hemorrhage?
Does oral glibenclamide improve functional outcomes and reduce cerebral edema in patients with aneurysmal subarachnoid hemorrhage?
Oral glibenclamide in subtherapeutic doses does not significantly improve functional or neurological outcomes in patients with aneurysmal subarachnoid hemorrhage and is associated with an increased risk of hypoglycemia.
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Glibenclamide confers no outcome benefit in aSAH; challenges prior signals and leaves larger trials needed before any clinical consideration.
AlBarakat et al. (2025) studied this question.
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