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February 2, 2026Stroke0 citations

Trends and Disparities in Alzheimer Disease and Stroke Mortality Among Older Adults

Abstract TP008: Trends and Disparities in Alzheimer Disease and Stroke-Related Deaths Among Older Adults in the United States: A CDC WONDER Analysis (1999-2023)

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Population

134,138 U.S. older adult deaths where stroke associated with Alzheimer's disease was an underlying or…

Design

Cohort

Follow-up

1999-2023

Key result

Mortality from stroke associated with Alzheimer’s disease in older adults declined since 1999, with the largest reductions observed after 2021.

Authors

SJSahil JairamaniFSFNU SahilRMRaam Mannam

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Overview

Supports surveillance of stroke-Alzheimer’s mortality trends; leaves open causal mechanisms behind recent declines and disparities.

Key Points

  • This research aims to analyze long-term trends and demographic disparities in mortality due to strokes associated with Alzheimer’s disease among older adults in the U.S.
  • Analyzed CDC WONDER mortality data from 1999 to 2023.
  • Calculated age adjusted mortality rates (AAMRs) per 100,000 using specific ICD codes.
  • Employed joinpoint regression to determine annual percent change (APC) stratified by sex, race, region, and urbanization.
  • Defined statistical significance as p < 0.05.
  • Identified 134,138 deaths involving strokes associated with Alzheimer’s disease from 1999-2023.
  • Women had higher AAMRs compared to men (13.86 vs. 11.03).
  • AAMRs were highest in non-Hispanic Black individuals (14.39), with significant geographic variation across states.
  • Post-2021, there was a pronounced decline in mortality rates across most demographics.

Structured PICO

P
Population
134,138 U.S. older adult deaths where stroke (ICD codes I60–I64) associated with Alzheimer's disease (ICD code G30) was an underlying or contributing cause between 1999 and 2023.
O
Outcome
Age-adjusted mortality rates (AAMRs) per 100,000 for stroke associated with Alzheimer's diseasehard clinical

Mortality from stroke associated with Alzheimer's disease in older adults has declined since 1999, though significant demographic and geographic disparities persist.

Cite This Study

Jairamani et al. (2026) studied this question. Mortality from stroke associated with Alzheimer’s disease in older adults declined since 1999, with the largest reductions observed after 2021.

synapsesocial.com/papers/6980fcb6c1c9540dea80e715https://doi.org/10.1161/str.57.suppl_1.tp008
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