What question did this study set out to answer?

This research aims to identify imaging biomarkers associated with infarct development in individuals with sickle cell disease.

February 2, 2026Stroke

Abstract A062: Assessment of predictive factors for infarct development in sickle cell disease

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Assessment of imaging biomarkers predicts infarct development in sickle cell disease, suggesting a need for aggressive therapies.

This research aims to identify imaging biomarkers associated with infarct development in individuals with sickle cell disease.
Participants aged 6-45 with sickle cell disease underwent two MRI scans over approximately one year.
Cerebral blood flow and oxygen extraction fraction were measured using specific MRI techniques.
A non-parametric Mann-Whitney test was performed to compare baseline measures between groups with and without new infarcts.
No significant differences in oxygen extraction fraction or cerebral blood flow between SCD+ and SCD- groups.
Higher dural venous shunting was observed in those who developed infarcts (SCD+ group) compared to those who did not (SCD- group), indicating increased risk.

Aumann et al. (2026) studied this question.

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