What question did this study set out to answer?

The research aims to evaluate the relationship between choroid plexus perfusion and cerebral health in individuals with sickle cell disease.

February 2, 2026Stroke

Abstract WP243: Choroid Plexus Perfusion in Sickle Cell Disease: an Imaging Biomarker of Brain Health?

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Examines choroid plexus perfusion in sickle cell disease, uncovering its potential as a brain health indicator.

The research aims to evaluate the relationship between choroid plexus perfusion and cerebral health in individuals with sickle cell disease.
Participants included adults with sickle cell disease and age-matched controls.
3T MRI and MRA scans assessed brain vascular health and perfusion levels.
Choroid plexus perfusion was measured using arterial spin labeling MRI and compared through linear regression analysis.
Total gray matter perfusion was significantly higher in SCD participants compared to controls.
Choroid plexus to gray matter perfusion ratio was significantly lower in SCD patients than in controls, indicating potential vascular issues.
A trend suggested further reduced ChP perfusion ratio in SCD patients with prior infarcts.

Jordan et al. (2026) studied this question.

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