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The aim is to classify subset variations of conventional dendritic cells in murine spleen and identify novel populations.

February 2, 2026PLoS ONEOpen Access

High-dimensional phenotyping reveals novel macrophage-like and hybrid subsets within murine splenic conventional dendritic cells

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The aim is to classify subset variations of conventional dendritic cells in murine spleen and identify novel populations.
Utilized multi-parametric flow cytometry for analysis.
Applied clodronate liposome (CL) depletion to examine cDC subsets.
Focused on CD11c high MHCII high cDCs in C57BL/6 mice.
Discovered three new dendritic cell subsets with distinct characteristics.
Identified a TZM-like subset resistant to CL depletion.
Found a F4/80 high APC subset sensitive to CL depletion.
Reported an unconventional CD4⁺CD8α⁺ hybrid population among cDCs.

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Identifies novel subsets of dendritic cells in mice, indicating a complex immune landscape.

Yang et al. (2026) studied this question.

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