Key result
Généreux stages ≥ 2 (vs stage 1) was associated with a 74% reduced likelihood of left ventricular reverse remodeling at 6 months in severe aortic regurgitation (OR 0.26; 95% CI 0.10-0.60; p=0.002).
Why the study?
Severe native aortic regurgitation causes progressive LV dysfunction and remodeling that intervention can partially reverse, but the predictive value of the Genereux staging classification for LV reverse remodeling was unknown.
Does Généreux staging classification predict left ventricular reverse remodeling in patients undergoing intervention for severe aortic regurgitation?
Cohort (n=103)
No
Does Généreux staging classification predict left ventricular reverse remodeling in patients undergoing intervention for severe aortic regurgitation?
Odds Ratio: 0.26 (95% CI 0.1–0.6)
p-value: p=0.002
Généreux staging classification is an independent prognostic factor for left ventricular reverse remodeling after intervention for severe aortic regurgitation, suggesting patients benefit most from intervention while in stage 1.
Généreux stages ≥2 associated with reduced early LVRR after AR intervention; hypothesis-generating for staging to guide timing.
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NESTA et al. (2026) conducted a cohort in Severe native aortic regurgitation (n=103). Généreux stages ≥ 2 vs. Généreux stage 1 was evaluated on Occurrence of left ventricular reverse remodeling (LVRR) defined as a significant reduction in left ventricle end systolic diameter and volume (OR 0.26, 95% CI 0.10-0.60, p=0.002). Généreux stages ≥ 2 (vs stage 1) was associated with a 74% reduced likelihood of left ventricular reverse remodeling at 6 months in severe aortic regurgitation (OR 0.26; 95% CI 0.10-0.60; p=0.002).
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