Expanding the scope of sustainable peptide synthesis through post-linear synthesis reactions

Michael A. Malone; Matilde De Francisco Craparotta; Kirsty I. M. Arnott; Andrew G. Jamieson; Nicola Wade

doi:10.1039/d5ob01890k

January 1, 2026Organic & Biomolecular ChemistryOpen Access

Expanding the scope of sustainable peptide synthesis through post-linear synthesis reactions

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Key Points

The aim is to explore sustainable alternatives for peptide synthesis beyond linear methods.
Replaced toxic solvent DMF with a sustainable solvent
Conducted reactions to synthesize complex peptidomimetics
Evaluated the effectiveness of the new solvent in post-linear synthesis
Successfully synthesized complex peptidomimetics without using DMF
Demonstrated the viability of sustainable solvents in peptide synthesis
Expanded the applications of sustainable peptide synthesis techniques

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Implication

Demonstrates the synthesis of complex peptidomimetics using a sustainable solvent, indicating an advancement in peptide synthesis techniques.

Abstract

We replace toxic solvent DMF with a sustainable solvent for reactions beyond linear peptide synthesis. This allows for complex peptidomimetics to be synthesised without DMF, expanding the field of sustainable peptide synthesis.

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Malone et al. (2026) studied this question.

synapsesocial.com/papers/6980feabc1c9540dea810ff3 https://doi.org/10.1039/d5ob01890k

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Expanding the scope of sustainable peptide synthesis through post-linear synthesis reactions

Key Points

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Abstract

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Expanding the scope of sustainable peptide synthesis through post-linear synthesis reactions

Key Points

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Implication

Abstract

Discussion

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