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February 2, 2026Analytical Chemistry

Dual-Mode Lateral Flow Assay for Simultaneous Quantification of Antibiotic and Bacteria

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Authors

ZXZeyong XuGuangdong Academy of Medical SciencesTWTing WuBeijing University of TechnologyBWBingjie WangGuangdong Academy of Medical Sciences

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Implication

This method demonstrates simultaneous quantification of antibiotic and bacteria in complex samples, indicating a significant advancement in detection technology.

Key Points

  • The aim is to develop a dual-mode lateral flow assay for the simultaneous detection of an antibiotic and a pathogen.
  • Utilized magnetic-SiO2-fluorescent probes for detection.
  • Integrated both sandwich and competitive formats on a single test strip.
  • Employed antibody-functionalized probes for capturing targeted molecules.
  • Validated performance with real environmental and food samples.
  • Achieved detection limits of 36 cfu/mL for Escherichia coli O157.
  • Reached detection limits of 2.05 pg/mL for gentamicin.
  • Demonstrated a 500-fold sensitivity improvement over traditional colorimetric methods.
  • Showed excellent reliability and stability in various sample types.

Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/6980fed9c1c9540dea811525https://doi.org/10.1021/acs.analchem.5c07200
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