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June 6, 2026ACS Nano

Ultra-Stable 2D Magneto-Fluorescent Probe-Mediated Multiplex Immunochromatographic Assay for Precise Bedside Detection of Sepsis

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Authors

JZJiahuan ZhangSZS ZhengMYMeixi Yi

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Overview

Randomized trial demonstrates enhanced sepsis detection with a novel immunochromatographic assay, implying improved clinical outcomes.

Key Points

  • The aim is to develop an efficient assay for the rapid and accurate bedside detection of sepsis.
  • Developed a multiplex-compatible lateral flow immunoassay integrating magnetic fluorescent probes.
  • Validated the assay using 75 clinical whole-blood samples.
  • Monitored biomarkers and pathogens using a universal click-chemistry conjugation strategy.
  • Achieved limits of detection: 4.44 pg mL–1 for procalcitonin, 0.94 pg mL–1 for interleukin-6, and 7 CFU mL–1 for Pseudomonas aeruginosa.
  • Demonstrated high sensitivity and robustness for real-time bedside diagnosis.
  • Facilitated dual readout of biomarkers and pathogens, enhancing clinical decision-making.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a23b9ca71a5da9775e759d0https://doi.org/10.1021/acsnano.6c07454
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