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Analysis evaluates safety profiles of minocycline, doxycycline, and chlorhexidine in periodontal therapy, suggesting a need for specific guidelines.
Adjunctive antimicrobial agents used in periodontal therapy demonstrate heterogeneous real-world safety signal profiles. Disproportionality patterns indicate that local administration does not preclude systemic biological relevance, underscoring the need for agent-specific, guideline-concordant risk-benefit assessment in clinical decision-making.
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Ning et al. (2026) studied this question.
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