Key result
CMR with native T1 and ECV achieves 100% positive predictive value for diagnosing cardiac amyloidosis.
Why the study?
Cardiac amyloidosis is a common yet underdiagnosed cause of heart failure with a hypertrophic phenotype in elderly patients, warranting evaluation of CMR with T1 imaging for diagnostic accuracy.
Does cardiac magnetic resonance imaging accurately diagnose cardiac amyloidosis in elderly patients with symptomatic heart failure and a hypertrophic phenotype?
Observational (n=112)
Does cardiac magnetic resonance imaging accurately diagnose cardiac amyloidosis in elderly patients with symptomatic heart failure and a hypertrophic phenotype?
Effect estimate: Accuracy 0.836 for native T1 and 0.904 for ECV
CMR with T1 mapping and ECV demonstrates high diagnostic accuracy for cardiac amyloidosis in elderly heart failure patients, allowing for a definite diagnosis in 56% of patients and potentially avoiding the need for contrast in a third of patients.
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May aid noninvasive CA diagnosis in elderly HF; extends observational data but leaves open need for validation.
Unger et al. (2026) conducted an observational in Symptomatic heart failure with risk factors for cardiac amyloidosis (n=112). Cardiac magnetic resonance (CMR) imaging with T1 mapping and extracellular volume fraction (ECV) was evaluated on Diagnostic accuracy to detect cardiac amyloidosis (Accuracy 0.836 for native T1 and 0.904 for ECV). Cardiac magnetic resonance imaging demonstrated high diagnostic accuracy (0.836 for native T1, 0.904 for ECV) for detecting cardiac amyloidosis in elderly patients with heart failure.
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