What question did this study set out to answer?

The aim is to develop a broad-spectrum SARS-CoV-2 vaccine that enhances immune response against viral variants.

February 2, 2026Frontiers in Cellular and Infection MicrobiologyOpen Access

A broad-spectrum SARS-CoV-2 RBD vaccine with selected high-impact mutations and novel adjuvant induces durable T cell response and broad protection in mice

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Authors

XCX ChenHenan University of Science and Technology YZYuzhen Zhang SYShimin YangWuhan Institute of Virology

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Implication

A broad-spectrum vaccine elicits durable T cell responses and neutralizing antibodies in mice, indicating potential for effective COVID-19 prevention.

Key Points

The aim is to develop a broad-spectrum SARS-CoV-2 vaccine that enhances immune response against viral variants.
Developed the M5-RBD vaccine using key high-impact mutations and extra mutations for evaluation.
Combined M5-RBD with the CpG adjuvant HP007 for improved immunization.
Compromised immune response was tested with M5-RBD containing specific mutations.
Evaluated immune responses using K18-hACE2 KI mice model.
M5-RBD produced high levels of neutralizing antibodies against various SARS-CoV-2 variants.
Inclusion of N440K or G446S mutations reduced immune response efficiency.
Together with HP007 adjuvant, M5-RBD induced robust and durable T cell responses.
Mice were protected against lethal challenges from both wild-type and Omicron BA.2 strains.

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/6980ff08c1c9540dea811aa7 https://doi.org/10.3389/fcimb.2025.1690554

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Implication

A broad-spectrum vaccine elicits durable T cell responses and neutralizing antibodies in mice, indicating potential for effective COVID-19 prevention.

A broad-spectrum SARS-CoV-2 RBD vaccine with selected high-impact mutations and novel adjuvant induces durable T cell response and broad protection in mice

Discussion

Member takes

Implication

Key Points

Cite This Study

A broad-spectrum SARS-CoV-2 RBD vaccine with selected high-impact mutations and novel adjuvant induces durable T cell response and broad protection in mice

Discussion

Member takes

Implication

Key Points

Cite This Study

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