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September 10, 2025Frontiers in ImmunologyOpen Access

Adjuvant combination and antigen multimerization shape neutralizing antibody and T cell responses to a SARS-CoV-2 RBD subunit vaccine

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Authors

JNJoão Pedro NunesMSMariângela de Oliveira SilvaJAJuliana de Souza Apostólico

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Overview

This study demonstrates enhanced neutralizing antibody and T cell responses using antigen multimerization and adjuvants in a SARS-CoV-2 RBD subunit vaccine.

Key Points

  • Immunization with RBD dimers and trimers elicited a stronger humoral response, indicating improved efficacy.
  • Using the adjuvant combination of AddaS03 and Poly I:C showed a synergistic effect on inducing long-lived memory plasma cells.
  • RBD-trimer immunization effectively inhibited viral replication in mice lungs challenged with the ancestral strain.
  • The study identified immunodominant CD4 and CD8 T cell epitopes within the RBD, highlighting T cell activation potential.

Cite This Study

Nunes et al. (2025) studied this question.

synapsesocial.com/papers/68c1aac654b1d3bfb60e316bhttps://doi.org/10.3389/fimmu.2025.1610422
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