What question did this study set out to answer?

This research aims to identify the risk factors and outcomes associated with severe infections in patients with AQP4-IgG neuromyelitis optica spectrum disorder.

February 2, 2026Multiple Sclerosis Journal

Predictive factors for immunosuppression-associated severe and opportunistic infections in AQP4-IgG Neuromyelitis Optica Spectrum Disorder

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Authors

GGGiacomo Greco SDSofia Delgado AFAnna FrancisJohn Radcliffe Hospital

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Implication

A retrospective analysis identifies infection risk factors in AQP4-IgG neuromyelitis optica, suggesting safer management strategies.

Key Points

This research aims to identify the risk factors and outcomes associated with severe infections in patients with AQP4-IgG neuromyelitis optica spectrum disorder.
Retrospective analysis of data from 209 AQP4-IgG NMOSD patients
Follow-up duration of at least one year
Definition of severe infections requiring hospitalization or intravenous therapy
Statistical identification of predictors using multivariate regression
49 severe or opportunistic infections occurred among 37 patients (18%)
One-third of deaths were linked to severe infections (10 out of 30 total deaths)
Independent predictors include longer disease duration and older age at onset
Comorbid autoimmune disease increases risk (OR 3.91)
Diabetes significantly raises infection risk (OR 7.48)

Cite This Study

Greco et al. (2026) studied this question.

synapsesocial.com/papers/6980ff08c1c9540dea811b34 https://doi.org/10.1177/13524585251409581

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Predictive factors for immunosuppression-associated severe and opportunistic infections in AQP4-IgG Neuromyelitis Optica Spectrum Disorder

Discussion

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Implication

Key Points

Cite This Study

Predictive factors for immunosuppression-associated severe and opportunistic infections in AQP4-IgG Neuromyelitis Optica Spectrum Disorder

Discussion

Member takes

Implication

Key Points

Cite This Study

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