ABSTRACT The synthesis of poly‐hetero‐aromatic (PHA) compounds via one‐pot green synthetic routes has emerged as a prominent and effective approach in contemporary organic synthesis. Throughout the decades, the synthesis of therapeutically important N‐heterocyclic compounds has been of interest to chemists. MCRs have been considered as a potential tool in achieving targeted N‐PHAs as they exhibit high atom economy by achieving complex scaffolds using simple starting units. MCRs using non‐metal catalysts and simpler reaction conditions are strong candidates for a greener synthetic approach. This review summarizes various protocols using only catalytic amounts of Bronsted acids ( p ‐TSA and CSA) or DMSO as the solvent cum reactant for the synthesis of complex quinolines and benzophenanthridines from elemental reagents in a single step. Such molecular frameworks hold substantial importance in drug discovery, as they exhibit a wide spectrum of biological and pharmacological activities. These methodologies assay the synthesis of diverse N‐PHAs in a regioselective manner following a greener synthetic approach.
Rani et al. (Sat,) studied this question.